Mandibular Metastasis from Nasopharyngeal Carcinoma

Authors

  • Hon Syn Chong Department of Otorhinolaryngology, Faculty of Medicine Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Mohd Razif Mohd Yunus Department of Otorhinolaryngology, Faculty of Medicine Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Chee Lun Lun Department of Otorhinolaryngology, Hospital Queen Elizabeth, Sabah, Malaysia

DOI:

https://doi.org/10.32412/pjohns.v26i2.571

Keywords:

Nasopharyngeal carcinoma, Bones, Mandible, Metastasis

Abstract

Objective:  To describe a case of mandibular metastasis from nasopharyngeal carcinoma and review the literature.

Methods:

Design:  Case Report

 

Setting:  Tertiary Public University Hospital

 

Patient:  One

 

Result:  A 42 year-old Malay gentleman underwent concurrent chemoradiotherapy (CCRT) for T4N2M0 (Stage IVa) nasopharyngeal carcinoma (NPC) non-keratinizing type (WHO II). Upon completion of CCRT, he developed metastasis to the left body of the mandible that increased in size despite 3 cycles of adjuvant intravenous chemotherapy. Hemi-mandibulectomy was deferred due to recent irradiation and a further 15 fractions of boost radiotherapy reduced the mandibular metastasis in size, but it has remained the same after six months follow up.

Conclusion:  Nasopharyngeal carcinoma (NPC) is a common malignancy in Oriental Asia and the South East Asian regions. It has the highest rates of nodal and distant metastases among all head and neck cancers. Distant metastasis to bone is common, but we could find no previous report of mandibular bone involvement in the literature.  Radiotherapy remains the main treatment modality and combination with chemotherapy has been shown to improve survival of patients. There are studies on nasopharyngeal carcinoma tumour markers for diagnosis and disease process follow up, but these are still inconclusive.

Keywords: Nasopharyngeal carcinoma, Bones, Mandible, Metastasis.

 

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Published

2011-12-03

How to Cite

1.
Chong HS, Yunus MRM, Lun CL. Mandibular Metastasis from Nasopharyngeal Carcinoma. Philipp J Otolaryngol Head Neck Surg [Internet]. 2011 Dec. 3 [cited 2024 Jul. 17];26(2):18-20. Available from: https://pjohns.pso-hns.org/index.php/pjohns/article/view/571