High Risk Human Papilloma Virus (HPV) Oropharyngeal Squamous Cell Carcinoma in a Private Tertiary Care Setting in the Philippines: Prevalence, Clinical Characteristics and Testing

Authors

DOI:

https://doi.org/10.32412/pjohns.v38i1.2141

Keywords:

human papillomavirus, oropharyngeal cancer, p16, squamous cell carcinoma

Abstract

ABSTRACT

Objective: To determine the prevalence and describe the clinical characteristics of high risk HPV mong patients with oropharyngeal squamous cell carcinomas in our institution utilizing p16 and HPV DNA in-situ hybridization testing and to determine the factors associated with high risk HPV positivity.
Methods:
     Design: Retrospective Cohort Review
     Setting: Tertiary Private Training Hospital
     Participants: 29
Results: A total of 29 primary oropharyngeal squamous cell carcinomas were diagnosed during the 11-year study period (January 2010 to December 2021). Based on the HPV in-situ hybridization status, the prevalence of high risk HPV oropharyngeal squamous cell carcinoma in our institution was 52%. Majority of these cases were males (87.5%) with a median age of ≤55 years old (60%) who are non-smokers (88.2%) and non-drinkers of alcoholic beverages (80%). There was no statistically significant association between age group, sex, smoking status, alcohol intake, lymph node status and high risk HPV infection. The most common tumor site involved in HPV-positive oropharyngeal squamous cell carcinoma was the tonsil (87%). Majority demonstrated a nonkeratinizing histology (73%) with positive lymph node status (67%) upon clinical presentation. Fifteen (83%) of the 18 p16 positive squamous cell carcinomas were positive for high risk HPVDNA. Of note, 3 (17%) out of the 18 p16 positive squamous cell carcinomas turned out to have negative HPV DNA-ISH status.
Conclusion: Although no statistically significant correlation between any clinical characteristic with viral status was established, HPV-mediated oropharyngeal squamous cell carcinoma in this institution was commonly seen among males aged 54 years old and below who are nonsmokers and non-drinkers of alcoholic beverages with the palatine tonsil as the most common site presenting with a non-keratinizing histology. In terms of testing, p16 staining correlates well with high risk HPV status. Future studies utilizing a larger patient population may aid in elucidating statistically significant clinical associations in our local population

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Published

2023-06-04

How to Cite

1.
Chang AM, Santos MK, Lim W. High Risk Human Papilloma Virus (HPV) Oropharyngeal Squamous Cell Carcinoma in a Private Tertiary Care Setting in the Philippines: Prevalence, Clinical Characteristics and Testing. Philipp J Otolaryngol Head Neck Surg [Internet]. 2023 Jun. 4 [cited 2024 Jul. 17];38(1):28. Available from: https://pjohns.pso-hns.org/index.php/pjohns/article/view/2141