Pneumococcal Conjugate Vaccine (Non-Typeable Haemophilus influenzae (NTHi) Protein D, Diphtheria or Tetanus Toxoid Conjugates) in Prevention of Acute Otitis Media in Children: A Cohort Study

Authors

  • Trixy G. Chu Department of Pediatrics University of Santo Tomas Hospital
  • Daniel Rafael R. Cachola, III. 2Department of Otorhinolaryngology-Head and Neck Surgery University of Santo Tomas Hospital
  • Mary Agnes S. Regal Department of Pediatrics University of Santo Tomas Hospital
  • Agnes Cecille G. Llamas Department of Pediatrics University of Santo Tomas Hospital
  • Norberto V. Martinez Department of Otorhinolaryngology-Head and Neck Surgery University of Santo Tomas Hospital
  • Wilfredo R. Santos Department of Pediatrics University of Santo Tomas Hospital

DOI:

https://doi.org/10.32412/pjohns.v31i2.223

Keywords:

Pneumococcal Conjugate Vaccine; Acute Otitis Media

Abstract

Objective: To compare the incidence of acute otitis media among children aged 2 to 6 months old in Sampaloc, Manila who were previously given 3 doses of pneumococcal conjugate vaccine (Non-Typeable Haemophilus influenzae (NTHi) protein D, diphtheria or tetanus toxoid conjugates) and those who did not receive the vaccine, over a period of one year.

Methods:

Study Design:             Cohort Study

Setting:                       Primary Health Center in Sampaloc, Manila, Philippines

Participants:              Medical records of well children aged 2 to 6 months were reviewed for inclusion. Participants were categorized into vaccinated and unvaccinated groups. Both groups underwent baseline history and physical examination including otoscopy and any signs and symptoms of active ear infection were noted.  Subjects were followed up for a period of 1 year on a monthly basis for signs or symptoms of acute otitis media.

Results: A total of 176 subjects participated in the study. The overall incidence of AOM among participants was 5.11% (9 out of 176). An AOM incidence of 3.75% (3 out of 80) and 6.25% (6 out of 96) was found among the exposed and unexposed groups, respectively. Fisher’s exact test (one-tailed) p value =.34, relative risk (RR) .6 (95 percent CI 0.155, 2.323).

Conclusion: The results of this study showed no difference in the development of AOM in the two groups. However, based on the relative risk, Pneumococcal conjugate vaccine is still beneficial in preventing AOM in children.

Keywords: Pneumococcal Conjugate Vaccine; Acute Otitis Media

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Published

2016-11-30

How to Cite

1.
Chu TG, Cachola DRR, Regal MAS, Llamas ACG, Martinez NV, Santos WR. Pneumococcal Conjugate Vaccine (Non-Typeable Haemophilus influenzae (NTHi) Protein D, Diphtheria or Tetanus Toxoid Conjugates) in Prevention of Acute Otitis Media in Children: A Cohort Study. Philipp J Otolaryngol Head Neck Surg [Internet]. 2016 Nov. 30 [cited 2024 Apr. 25];31(2):13-5. Available from: https://pjohns.pso-hns.org/index.php/pjohns/article/view/223

Issue

Vol. 31 No. 2 (2016): Philippine Journal of Otolaryngology-Head and Neck Surgery

Section

Original Articles

License

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