Sinonasal Ameloblastic Carcinoma in a 50-Year-Old Filipino Female
DOI:
https://doi.org/10.32412/pjohns.v30i2.351Keywords:
sinonasal, maxillary, ameloblastic carcinoma, malignant transformationAbstract
Objective: To report the possible malignant transformation of primary sinonasal ameloblastoma into sinonasal ameloblastic carcinoma.
Methods:
Design: Case Report
Setting: Tertiary Public University Hospital
Patient: One (1)
Result: A 50-year-old woman with a previous diagnosis of sinonasal ameloblastoma reported recurrence of symptoms of right-sided nasal obstruction and epistaxis two years after endoscopic sinus surgery. Clinical examination, CT scans, and subsequent total maxillectomy with orbital exenteration revealed a left intranasal mass with maxillary, ethmoid, and orbital floor extension and pulmonary and hepatic metastases. Histopathologic findings of palisading columnar epithelium with reverse polarity with malignant features were consistent with ameloblastic carcinoma. Despite subsequent cycles of chemotherapy, the patient died two years after surgery. To the best of our knowledge, there have been no published reports of a primary sinonasal ameloblastoma with malignant transformation in the English literature.
Conclusion: Ameloblastic carcinoma is a rare neoplasm which may arise de novo or from malignant transformation of an ameloblastoma. Because ameloblastoma is commonly encountered in our setting, clinicians should be aware of this possibility and closely follow their patients accordingly.
Keywords: sinonasal, maxillary, ameloblastic carcinoma, malignant transformation
Downloads
Published
How to Cite
Issue
Section
License
Copyright transfer (all authors; where the work is not protected by a copyright act e.g. US federal employment at the time of manuscript preparation, and there is no copyright of which ownership can be transferred, a separate statement is hereby submitted by each concerned author). In consideration of the action taken by the Philippine Journal of Otolaryngology Head and Neck Surgery in reviewing and editing this manuscript, I hereby assign, transfer and convey all rights, title and interest in the work, including copyright ownership, to the Philippine Society of Otolaryngology Head and Neck Surgery, Inc. (PSOHNS) in the event that this work is published by the PSOHNS. In making this assignment of ownership, I understand that all accepted manuscripts become the permanent property of the PSOHNS and may not be published elsewhere without written permission from the PSOHNS unless shared under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
