Sinonasal Mucosal Melanoma: An Enigma

Authors

  • Hidayat Ullah Department of ENT BRD Medical College, Gorakhpur, India
  • Mirza Qaisar Baig Department of ENT BRD Medical College, Gorakhpur, India

DOI:

https://doi.org/10.32412/pjohns.v26i1.603

Keywords:

mucosal melanoma, sinonasal cavity

Abstract

Objective: To report two cases of mucosal melanoma of the sinonasal cavity from India and

review the literature emphasizing current important clinical and biologic aspects of this tumor.

 

Methods:

Design: Case Report

Setting: Tertiary Public Referral Hospital

Patients: Two

 

Results: Two patients presenting with progressive unilateral nasal obstruction over three to six

months, respectively, were diagnosed to have sinonasal mucosal melanoma. The mass involved

the nasal cavity and maxillary antrum in both patients. The first patient deferred radiotherapy for

four months until pulmonary metastasis became evident, necessitating palliative chemotherapy;

the second patient underwent surgical excision and radiotherapy.

 

Conclusion: In spite of aggressive therapy, the prognosis for people with mucosal melanoma

is extremely poor. Surgery remains the mainstay of treatment, although adjuvant radiation

therapy has recently had an increasing role in the treatment of mucosal melanoma. A clear

understanding of the pathophysiology of this disease may yield more specific immunotherapy

and chemotherapy techniques. A multicenter prospective study is required to objectively assess

the optimal treatment regimen.

 

Keywords: mucosal melanoma, sinonasal cavity

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Published

2011-06-27

How to Cite

1.
Ullah H, Baig MQ. Sinonasal Mucosal Melanoma: An Enigma. Philipp J Otolaryngol Head Neck Surg [Internet]. 2011 Jun. 27 [cited 2024 Nov. 24];26(1):34-8. Available from: https://pjohns.pso-hns.org/index.php/pjohns/article/view/603

Issue

Vol. 26 No. 1 (2011): Philippine Journal of Otolaryngology-Head and Neck Surgery

Section

Case Reports

License

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