Risk Factors for Recurrent Papillary Thyroid Carcinoma

Authors

  • Jonel Donn Leo S. Gloria Department of Otorhinolaryngology University of the Philippines – Philippine General Hospital
  • Alfredo Quintin Y. Pontejos Department of Otorhinolaryngology University of the Philippines – Philippine General Hospital
  • Precious Eunice R. Grullo Department of Otorhinolaryngology University of the Philippines – Philippine General Hospital

DOI:

https://doi.org/10.32412/pjohns.v32i2.71

Keywords:

papillary thyroid cancer, thyroid neoplasm, recurrence

Abstract

Objective:  To identify risk factors associated with disease recurrence among Filipinos with papillary thyroid carcinoma (PTC).

Methods:

Design:           Retrospective cohort study

Setting:           Tertiary National University Hospital

Participants: 76 patients diagnosed with papillary thyroid carcinoma, classified as low and low-to-intermediate risk (2015 ATA classification) that underwent total thyroidectomy with or without neck dissection from 2010-2014 and were followed up from 10 months to 5 years. Log rank and Cox regression analyses were used to determine significant risk factors for recurrence.

Results:  29 (38.15%) had recurrence.  On univariate analysis, age, tumor size, multifocality, extrathyroidal extension, presence of lateral neck nodes and RAI therapy were statistically associated with recurrence.  However, on multivariate analysis, no clinicopathologic factor was statistically associated with recurrence.

Conclusion: Age of >45 years, female sex, tumor size of >2 cm, multifocality, presence of microscopic extrathyroidal extension, and lymph node metastasis might contribute to the recurrence of papillary thyroid cancer while post-operative radioactive ablation may have some protective effect.  However, this study suggests that other factors must be included in the model to better understand the relationship between these factors and recurrence.

 

Keywords: papillary thyroid cancer, thyroid neoplasm, recurrence

Downloads

Download data is not yet available.

Downloads

Published

2018-07-24

How to Cite

1.
Gloria JDLS, Pontejos AQY, Grullo PER. Risk Factors for Recurrent Papillary Thyroid Carcinoma. Philipp J Otolaryngol Head Neck Surg [Internet]. 2018 Jul. 24 [cited 2024 Nov. 21];32(2):25-9. Available from: https://pjohns.pso-hns.org/index.php/pjohns/article/view/71

Issue

Vol. 32 No. 2 (2017): Philippine Journal of Otolaryngology-Head and Neck Surgery

Section

Original Articles

License

Copyright transfer (all authors; where the work is not protected by a copyright act e.g. US federal employment at the time of manuscript preparation, and there is no copyright of which ownership can be transferred, a separate statement is hereby submitted by each concerned author). In consideration of the action taken by the Philippine Journal of Otolaryngology Head and Neck Surgery in reviewing and editing this manuscript, I hereby assign, transfer and convey all rights, title and interest in the work, including copyright ownership, to the Philippine Society of Otolaryngology Head and Neck Surgery, Inc. (PSOHNS) in the event that this work is published by the PSOHNS. In making this assignment of ownership, I understand that all accepted manuscripts become the permanent property of the PSOHNS and may not be published elsewhere without written permission from the PSOHNS unless shared under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.