Levothyroxine versus Levothyroxine with Iodine in Reduction of Thyroid Nodule Volume: A Double-Blind Randomized Controlled Trial

  • Donnie Jan D. Segocio Department of Otorhinolaryngology Head and Neck Surgery Southern Philippines Medical Center
  • Joseph E. Cachuela Department of Otorhinolaryngology Head and Neck Surgery Southern Philippines Medical Center
Keywords: thyroid nodule, prevention and control, drug therapy, iodine compounds, therapeutic use, levothyroxine, therapeutic use

Abstract

Objective: To compare levothyroxine alone and in combination with iodine on thyroid nodule volume reduction.

Methods:

          Design:           Double-Blind Randomized Controlled Trial

          Setting:           Tertiary Government Hospital

          Participants: Nineteen (19) euthyroid patients age 19­-54 with at least 1 cytologically benign thyroid nodule were randomized to receive either levothyroxine + iodine or levothyroxine + placebo, taken once a day for 6 months with ultrasound and thyroid stimulating hormone monitoring on the 3rd and 6th month of intervention.

Results: Main outcome measures included thyroid nodule volume reduction after six months of intervention. The mean change in volume from baseline to six months of levothyroxine + iodine group showed no statistically significant difference in nodule volume across time between  levothyroxine + placebo group, -0.010 ± 1.250 (CI -0.521 - 0.501) versus 0.507 ± 1.128 (CI 0.025 - 0.990), p=.158.  There were also new nodules (4 nodules) in the placebo group and none in the iodine group. No major adverse events were noted during the study.

Conclusion: The two groups did not significantly differ in terms of nodule volume reduction.

Keywords: thyroid nodule, prevention and control; drug therapy; iodine compounds, therapeutic use; levothyroxine, therapeutic use

Downloads

Download data is not yet available.
Published
2019-06-18
How to Cite
1.
Segocio DJD, Cachuela JE. Levothyroxine versus Levothyroxine with Iodine in Reduction of Thyroid Nodule Volume: A Double-Blind Randomized Controlled Trial. Philipp J Otolaryngol Head Neck Surg [Internet]. 2019Jun.18 [cited 2019Sep.19];34(1):14-9. Available from: https://pjohns.pso-hns.org/index.php/pjohns/article/view/959