A Preliminary Study on the Efficacy of Plumeria acuminata (Kalachuchi) Bark Extract Ointment versus Clotrimazole Cream in the Treatment of Otomycosis

Authors

  • Rhoda Mae V. Boncalon Department of Otorhinolaryngology – Head & Neck Surgery Western Visayas Medical Center
  • Marida Arend V. Arugay Department of Otorhinolaryngology – Head & Neck Surgery Western Visayas Medical Center
  • Rachel Zita H. Ramos Department of Otorhinolaryngology – Head & Neck Surgery Western Visayas Medical Center

DOI:

https://doi.org/10.32412/pjohns.v24i1.701

Keywords:

Otomycosis, kalachuchi, Plumeria acuminata Ait, clotrimazole, clinical trial, herbal medicine

Abstract

Objective:  To compare the therapeutic efficacy of kalachuchi (Plumeria acuminata Ait.) bark extract ointment (KO) and clotrimazole cream 1% (CC) in the treatment of otomycosis.

Methods:

Design:  Randomized double blind controlled trial

Setting: Outpatient otorhinolaryngology clinic of a tertiary private hospital

Subjects: Patients aged 18-years-old and above diagnosed clinically to have otomycosis with a positive potassium hydroxide (KOH) smear were randomly assigned to kalachuchi (Plumeria acuminata Ait.) bark extract ointment or clotrimazole cream 1% in unlabeled containers.  Self-application thrice daily for two weeks followed initial detailed instructions and demonstration. Symptoms, physical findings and repeat KOH smears were recorded after the first and second weeks of treatment.

Results:  Eighteen patients with otomycosis were enrolled in the study.  There was one  dropout per treatment group with no intention to treat. There were no statistically significant differences between KO and CC, with 75% (n=8) and 87.5% (n=8) cure rates, respectively.  One subject in the KO arm reported severe ear pain.

Conclusion: Kalachuchi extract ointment may be a promising topical antifungal agent. Multicenter clinical trials to establish its efficacy and safety as an effective alternative in the management of otomycosis should be conducted.

Key words: Otomycosis, kalachuchi, Plumeria acuminata Ait., clotrimazole, clinical trial, herbal medicine

           

Downloads

Download data is not yet available.

Downloads

Published

2009-06-15

How to Cite

1.
Boncalon RMV, Arugay MAV, Ramos RZH. A Preliminary Study on the Efficacy of Plumeria acuminata (Kalachuchi) Bark Extract Ointment versus Clotrimazole Cream in the Treatment of Otomycosis. Philipp J Otolaryngol Head Neck Surg [Internet]. 2009 Jun. 15 [cited 2022 Aug. 19];24(1):5-8. Available from: https://pjohns.pso-hns.org/index.php/pjohns/article/view/701