Odontogenic Ghost Cell Carcinoma of the Maxilla
This is from a 39-year-old male with a 26-six-year history of a maxillary mass, recurring after excision, 10cm in widest diameter, solid and cystic.
Odontogenic ghost cell carcinomas (OGCC) are rare and only a dozen or so have been reported in the literature. This tumor appears to be more common in Asians based on the cases that have been reported and is more common in the maxilla than the mandible. Histologically, elements of a benign calcifying odontogenic cyst (COC) can be identified in all the malignant variants, either separated or admixed with the malignant epithelial component. The biological behavior of the tumour is unpredictable, with some cases characterized by relatively indolent growth and others by a locally aggressive and potentially fatal course. The tumour apparently arises most often from malignant transformation of a preexisting benign COC, although it may also develop from other odontogenic tumours. The section shows cords and islands of stellate reticulum displaying peripheral palisading of ameloblasts. There are numerous polygonal cells that have eosinophilic cytoplasm and indistinct cellular detail (“ghost cells”). Calcified dental matrix is also present. Although cytologic atypia appears mild, the borders are infiltrative.
How to Cite
Copyright transfer (all authors; where the work is not protected by a copyright act e.g. US federal employment at the time of manuscript preparation, and there is no copyright of which ownership can be transferred, a separate statement is hereby submitted by each concerned author). In consideration of the action taken by the Philippine Journal of Otolaryngology Head and Neck Surgery in reviewing and editing this manuscript, I hereby assign, transfer and convey all rights, title and interest in the work, including copyright ownership, to the Philippine Society of Otolaryngology Head and Neck Surgery, Inc. (PSOHNS) in the event that this work is published by the PSOHNS. In making this assignment of ownership, I understand that all accepted manuscripts become the permanent property of the PSOHNS and may not be published elsewhere without written permission from the PSOHNS unless shared under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.