Odontogenic Ghost Cell Carcinoma of the Maxilla

Authors

  • Ella C. Lim Department of Pathology, Philippine General Hospital, University of the Philippines Manila
  • Jose M. Carnate Department of Pathology, College of Medicine – Philippine General Hospital,University of the Philippines Manila
  • Jose Ma. C. Avila Department of Pathology, College of Medicine – Philippine General Hospital,University of the Philippines Manila

DOI:

https://doi.org/10.32412/pjohns.v21i1-2.845

Keywords:

carcinoma

Abstract

This is from a 39-year-old male with a 26-six-year history of a maxillary mass, recurring after excision, 10cm in widest diameter, solid and cystic.

 

Odontogenic ghost cell carcinomas (OGCC) are rare and only a dozen or so have been reported in the literature. This tumor appears to be more common in Asians based on the cases that have been reported and is more common in the maxilla than the mandible. Histologically, elements of a benign calcifying odontogenic cyst (COC) can be identified in all the malignant variants, either separated or admixed with the malignant epithelial component. The biological behavior of the tumour is unpredictable, with some cases characterized by relatively indolent growth and others by a locally aggressive and potentially fatal course. The tumour apparently arises most often from malignant transformation of a preexisting benign COC, although it may also develop from other odontogenic tumours. The section shows cords and islands of stellate reticulum displaying peripheral palisading of ameloblasts. There are numerous polygonal cells that have eosinophilic cytoplasm and indistinct cellular detail (“ghost cells”). Calcified dental matrix is also present. Although cytologic atypia appears mild, the borders are infiltrative.

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Published

2006-11-29

How to Cite

1.
Lim EC, Carnate JM, Avila JMC. Odontogenic Ghost Cell Carcinoma of the Maxilla. Philipp J Otolaryngol Head Neck Surg [Internet]. 2006 Nov. 29 [cited 2024 Jun. 23];21(1-2):56. Available from: https://pjohns.pso-hns.org/index.php/pjohns/article/view/845